Nefopam and Alfentanil Additively Reduce the Shivering Threshold in Humans whereas Nefopam and Clonidine Do Not
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چکیده
منابع مشابه
Nefopam and alfentanil additively reduce the shivering threshold in humans whereas nefopam and clonidine do not.
BACKGROUND Induction of therapeutic hypothermia is often complicated by shivering. Nefopam reduces the shivering threshold with minimal side effects. Consequently, nefopam is an attractive component for induction of therapeutic hypothermia. However, nefopam alone is insufficient; it will thus need to be combined with another drug. Clonidine and alfentanil each reduce the shivering threshold. Th...
متن کاملDexmedetomidine and meperidine additively reduce the shivering threshold in humans.
BACKGROUND AND PURPOSE Hypothermia might prove to be therapeutically beneficial in stroke victims; however, even mild hypothermia provokes vigorous shivering. Meperidine and dexmedetomidine each linearly reduce the shivering threshold (triggering core temperature) with minimal sedation. We tested the hypothesis that meperidine and dexmedetomidine synergistically reduce the shivering threshold w...
متن کاملNefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects.
BACKGROUND The analgesic nefopam does not compromise ventilation, is minimally sedating, and is effective as a treatment for postoperative shivering. The authors evaluated the effects of nefopam on the major thermoregulatory responses in humans: sweating, vasoconstriction, and shivering. METHODS Nine volunteers were studied on three randomly assigned days: (1) control (saline), (2) nefopam at...
متن کاملMeperidine and skin surface warming additively reduce the shivering threshold: a volunteer study
INTRODUCTION Mild therapeutic hypothermia has been shown to improve outcome for patients after cardiac arrest and may be beneficial for ischaemic stroke and myocardial ischaemia patients. However, in the awake patient, even a small decrease of core temperature provokes vigorous autonomic reactions-vasoconstriction and shivering-which both inhibit efficient core cooling. Meperidine and skin warm...
متن کاملOndansetron does not reduce the shivering threshold in healthy volunteers.
BACKGROUND Ondansetron, a serotonin-3 receptor antagonist, reduces postoperative shivering. Drugs that reduce shivering usually impair central thermoregulatory control, and may thus be useful for preventing shivering during induction of therapeutic hypothermia. We determined, therefore, whether ondansetron reduces the major autonomic thermoregulatory response thresholds (triggering core tempera...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2009
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3181a979c1